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176,177,178 Notably, in individuals of European ancestry, the genetic control of SLC2A9a and SLC2A9b isoforms, situated at basolateral and apical membranes respectively, constitutes a prominent genetic signal

iNOS, Inducible nitric oxide synthase

Because the effects of rescue medications (e.g., basal and bolus insulin) are already included in treatment policy estimands, disease modelling which equally applies treatment effects of subsequent treatments (e.g., basal and bolus insulin) following formally modelled treatment switching/intensification biases results against better-performing treatments with lower use of rescue medications